锦鲤求职岗位描述
Senior Scientist(Chemistry), LNP platform
Responsibilities：
1. LNP/t-LNP Formulation and Process Development.
• Develop LNP delivery systems for mRNA, sgRNA, siRNA, DNA, and other nucleic acid payloads.
• Design and optimize ionizable lipid, helper lipid, cholesterol, PEG-lipid, and related formulation components.
• Develop and optimize microfluidic and/or rapid-mixing processes for LNP preparation.
• Optimize critical formulation and process parameters, including N/P ratio, lipid composition, aqueous-to-organic phase ratio, mixing conditions, buffer composition, and downstream processing conditions.
2. Targeted LNP (t-LNP) platform development
• Develop surface-targeting strategies for LNPs using antibodies, VHHs, scFvs, peptides, ligands, and other targeting moieties.
• Develop ligand conjugation strategies, including maleimide-based and click-chemistry approaches.
• Optimize key parameters including surface ligand density, conjugation efficiency, and removal of unconjugated/free ligand.
• Assist in establishing physicochemical characterization and functional evaluation methods for t-LNPs.
• Investigate the relationship between surface ligand density, cellular uptake, tissue distribution, and in vivo delivery efficiency.
• Develop t-LNP delivery strategies for specific target cell populations and tissues.
Qualifications:
1. PhD degree, preferably graduating in 2026 or recently graduated, in Pharmaceutical Sciences, Pharmaceutics, Chemical Engineering, Biomedical Engineering, Chemistry, Materials Science, Biochemistry, Molecular Biology, or a related field.
2. Demonstrated research experience in at least one of the following areas:
• LNP / lipid nanoparticles
• Nucleic acid delivery
• Nanomedicine / drug delivery
• Targeted delivery
• Lipid chemistry
• Nanoparticle formulation
3.Strong ability to conduct independent research, including experimental design, execution, data analysis, and interpretation.
4. Hands-on experience with at least one LNP preparation technology, such as microfluidics, T-junction mixing etc.
5. Familiarity with LNP physicochemical characterization and analytical methods.
6. Strong English scientific literature reading, technical writing, and communication skills.
7. Strong analytical thinking, learning ability, and scientific problem-solving skills.